Plenary paper Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex
نویسندگان
چکیده
1Inserm, Unité U768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Paris, France; 2Inserm, Institut Fédératif de Recherche Necker Enfants-Malades (IFR94), Université Paris Descartes, Paris, France; 3Imagine Institute, Paris, France; 4Inserm, Unité U1038, Grenoble, France; 5Commisariat à l’énergie atomique, Direction des sciences du vivant, Institut de Recherches en technologies et science du vivant, Laboratoire de Biologie à Grandes Echelle, Grenoble, France; 6Université Joseph Fourier, Grenoble, France; and 7Assistance Publique–Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Unité d’Immunologie-Hématologie Pédiatrique, Paris, France
منابع مشابه
Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.
Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at the immune synapse. The lytic granules are initially recruited around the polarized microtubule-organizing center. In a dynein-dependent transport process, the granules move along microtubules toward the microtubule-organizing center in the minus-end direction. Here, we found that a kinesin-1-dependen...
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Natural killer (NK) lymphocytes contain lysosome-related organelles (LROs), known as lytic granules, which upon formation of immune synapse with the target cell, polarize toward the immune synapse to deliver their contents to the target cell membrane. Here, we identify a small GTP-binding protein, ADP-ribosylation factor-like 8b (Arl8b), as a critical factor required for NK cell-mediated cytoto...
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CD8+ cytotoxic T lymphocytes (CTLs) eliminate virally infected cells through directed secretion of specialized lytic granules. Because a single CTL can kill multiple targets, degranulation must be tightly regulated. However, how CTLs regulate the termination of granule secretion remains unclear. Previous work demonstrated that centralized actin reduction at the immune synapse precedes degranula...
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